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Now, a major new study shows that the virus spike proteins (which behave very differently than those safely encoded by vaccines) also play a key role in the disease itself. eCollection 2018 Aug. Li P, Shan Y, Zheng W, Ou X, Mi D, Mu Z, Holmes KV, Qian Z. J Virol. The statements contained on my sites and in my books have not been evaluated by the FDA. 2020;181:271280.e278. Yes, just the spike protein, without the whole virion or its genome. But that does not seem what the COVID vaccines are doing. Prevention and treatment information (HHS). product of genetic engineering of the worst kind, have dramatic changes in menstruation, according to the British Medical Journal, might explain why even unvaccinated women exposed to vaccinated women are having similar problems, self-replicating vaccines could indeed entail serious risks, At Least 9,245 Americans Tested Positive for COVID-19 After Vaccination; 132 Dead, highly uncommon side effects of respiratory diseases, starting to believe that the spike proteins made from vaccinated peoples cells are transmittable, is the same one found on the viruss surface, causing the damage to distant organs that may include the brain, heart, lung, and kidney, enhanced the brain uptake of spike proteins, overweight people are more likely to suffer from serious coronavirus infections, do not find viral RNA in brain endothelium. The coronavirus spike protein is a multifunctional molecular machine that mediates coronavirus entry into host cells. This confirmed that the new viruss spike protein also is a shape-shifter. The researchers also uncovered evidence that subunit 2 of the SARS-CoV-2 spike protein Found insideThis book presents a comprehensive overview of important immune molecules and their structure-function relationships. COVID Vaccines Causing Microvascular Injuries, Back in December 2020, Dr. J. Patrick Whelan of UCLA sent a warning to the FDA. Privacy, Help This allows them to get entry into those cells. (, Crystal structures of alphacoronavirus S1 C-terminal domains (S1-CTDs). Homology modeling is an in silico method that predicts the tertiary structure of an amino acid sequence based on a homologous experimentally determined structure. The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. Spike protein QTC10874.1 is the earliest collected V4 sample on 14.01.2021 in Spain. ( a ) Trimeric mouse, Crystal structures of betacoronavirus S1, Crystal structures of betacoronavirus S1 C-terminal domains (S1-CTDs). During infection, the spike proteins bind with receptors on cells in our body, starting a process that allows the virus to release its genetic material into the inside of the healthy cell. Spike protein has therefore been selected as an important target for coronavirus vaccine and anti-viral development. Would you like email updates of new search results? The CDC had stated that the spike protein of SARS-CoV-2 isharmless, which assures that current Covid-19 vaccines would be safe.Could they be wrong? Epub 2021 Aug 21. (, Crystal structures of betacoronavirus S1 C-terminal domains (S1-CTDs). 2021 Jun 29;9(7):706. doi: 10.3390/vaccines9070706. Nature. Whats more, it clings to its target on human cells 10 to 20 times as tightly as the SARS spike protein When our cells make the spike protein, they would like us to believe that ourimmune responsewill recognize it as foreign and start making antibodies and T cells that specifically target it. The author declares no conflict of interest. Two domains in S1 from different coronaviruses recognize a variety of host receptors, leading to viral attachment. The spike protein is an arm-like apparatus that the virus uses to attach to and enter healthy cells. The feasibility of inhaled RNA for passive transfection has been proven in several studies. Just the spike protein lingering around may Associated with the viral envelope are at least three structural proteins: The membrane protein (M) and the envelope protein (E) are involved in virus assembly, whereas the spike protein (S) mediates virus entry into host cells. Subscribe to Dr. Sircus's newsletter and receive for free The Innovative Medicine ebook and introductory articles that will guide you through his protocol and the medicinals that compose it. Epub 2012 Jun 20. On 1/18/2021, she began to have heavy vaginal bleeding probably due to a placental abruption and subsequently delivered at 18 weeks. The N-terminal domain (NTD) of the Spike protein plays a regulatory function Second pregnancy. coronavirus NSP1 proteins employ divergent mechanisms to suppress host protein expression (4). doi: 10.7554/eLife.61552. The COVID vaccines (from Oxford/AstraZeneca, Pfizer/BioNTech, and Moderna) all work by getting our cells to make copies of the virus spike protein. A Tel Aviv-based start-up company claims it has proven in lab results that a combination of plant-based natural compounds can decompose the Yet the mainstream press, Youtube, Facebook, Twitter, the CDC, FDA, WHO, the vaccine companies, and everyone who is mandating COVID vaccines are ignoring the thousands of people dropping dead soon after their shots and the hundreds of thousands of injured, tens of thousands seriously, all of which are being counted in Europe and the United States by official vaccine reporting systems. Doctor of Oriental and Pastoral Medicine -, Ou X., Liu Y., Lei X., Li P., Mi D., Ren L., Guo L., Guo R., Chen T., Hu J., et al. inactivate tumor-suppressing proteins and thereby promote cancer. eCollection 2020 Mar. Domain structure of SARS-S and SARS-2-S. ( A ) Key domains in SARS-S, Cleavage sites at the S1/S2 boundary. This book contemplates the structure, dynamics and physics of virus particles: From the moment they come into existence by self-assembly from viral components produced in the infected cell, through their extracellular stage, until they SARS-2-S is cleaved into S1 and S2 subunits, with S1 serving the function of receptor-binding and S2 serving the function of membrane fusion. Spike protein QTC10874.1 is the earliest collected V4 sample on 14.01.2021 in Spain. be enough to trigger biological problems, such as vascular thickening. Yang Q, Hughes TA, Kelkar A, Yu X, Cheng K, Park S, Huang WC, Lovell JF, Neelamegham S. Elife. The transition from prefusion to postfusion conformation of the spike protein must be triggered, leading to membrane fusion. first vaccine death of a two-year-old reported into the VAERS vaccine reporting system. This third edition of A Dictionary of Virology offers an authoritative, concise, and up-to-date list of all viruses affecting vertebrate species, from humans to fish. -, Hoffmann M., Kleine-Weber H., Phlmann S. A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells. The S protein is a highly glycosylated and large type I transmembrane fusion protein that is made up of 1,160 to 1,400 amino acids, depending upon the type of virus. This site needs JavaScript to work properly. For this cluster, variant V4 read the excuses for the terrifying world of genetic engineering. Prevention and treatment information (HHS). Perhaps it is not the virus itself that is wreaking biological havoc but the spike protein itself. Accompanyind CR-ROM conrtains The Encyclopedia of Materials Science and Technology on a web access disc. ( a ) Structural comparison between human galectins and, MeSH The S protein plays a crucial role in penetrating host cells and initiating infection.. Professor of Natural Oncology, Da Vinci Institute of Holistic Medicine At the tip of the spike protein rests a string of three amino acids called RGD. LA JOLLAScientists have known for a while that SARS-CoV-2s distinctive spike proteins help the virus infect its host by latching on to healthy cells. This is because the inflammation had disrupted the blood-brain barrier integrity, making it more permeable to foreign invaders. This would explain why overweight people are more likely to suffer from serious coronavirus infections, with the associated risk especially prevalent among those younger than 40, according to a new study. Those instructions are carried via messenger RNA, ormRNA. Subscribe to Dr. Sircus's newsletter and receive for free an ebook and introductory articles that will guide you through his protocol and the medicinals that compose it. Online ahead of print. The Spike Protein is a uniquely dangerous transmembrane fusion protein that is an integral part of the SARS-CoV-2 virus. Spike proteins produced by the body might also explain why so many women, not reported into the vaccine reporting systems, have dramatic changes in menstruation, according to the British Medical Journal. Is it possible the spike protein itself causes SARS-CoV-2 Production in a Scalable High Cell Density Bioreactor. Interest in the coronaviruses has never been greater. Their economic impact is considerable as they infect humans, livestock, poultry and companion animals. Nicholas Evans, a masters student at the Texas Tech University Health Sciences Center, said, Symptoms seen in patients may initially result from the spike protein interacting with the cells directly. The inference is that the spikes make long-term changes to human lung cells, which speaks of a medical disaster doctors have not confronted before. Two domains in S1 from different coronaviruses recognize a variety of host receptors, leading to viral attachment. Clipboard, Search History, and several other advanced features are temporarily unavailable. Coronavirus Pseudotypes for All Circulating Human Coronaviruses for Quantification of Cross-Neutralizing Antibody Responses. Disclaimer, National Library of Medicine 2021 Jul 8;12:663912. doi: 10.3389/fimmu.2021.663912. Researchers at the Sloan Kettering Institute have found that changes Dr. Lee Makowski from Northeastern University published his hypothesisin the journalViruses, believes the spike protein found on the surface of the virus might mimic proteins that regulate blood vessels and control the formation of blood clots, which could explain many of the non-respiratory complications of COVID-19. Once the instructions (mRNA) are inside the muscle cells, the cells use them to make the protein piece. Baby was stillborn. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes. The integration of structure and function of SARS-2-S in this review should enhance our understanding of the dynamic processes involving receptor binding, multiple cleavage events, membrane fusion, viral entry, as well as the emergence of new viral variants. [1] VAERS: Write-up: Pt was 18 weeks pregnant at the time of the vaccine. This volume offers an overview of the processes of zoonotic viral emergence, the intricacies of host/virus interactions, and the role of biological transitions and modifying factors. How can anyone with a human heart deny the death and deep suffering of others? The volume includes articles by all of the major contributors to this burgeoning area of research which summarize the work presented at the meeting. This represents the only comprehensive book to cover this field in the last five years. A pineapple enzyme, bromelain, has been successfully used to inhibit COVID-19 infection but has double-action to break up clots and block spike protein. doi: 10.1146/annurev-virology-110615-042301. Join 90,000 others in my newsletter and get a free ebook! SARS-CoV-2 may not need to complete viral infection and replication Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. See this image and copyright information in PMC. FOIA doi: 10.1126/science.1116480. Pathogenesis and Immunity, the second volume of The Flaviviruses, examines the processes by which the flaviviruses cause disease, the different cytopathic effects and the associated immunopathological responses produced in their hosts. * New to this Edition New author team - one main author to ensure that the book reads like an authored book but with the benefit of using experts to contribute to specific topics Text has been refocused - part I has been condensed and where 2005;309:18641868. The vaccines spike protein responsible for infection and its most severe symptoms would remain mostly in the injection site at the shoulder muscle or local lymph nodes. Commun. The more overweight a person is, the more we find chronic inflammation in the body. Learn Dr Sircus protocol including dosages, methods, side effects and contra-indications. The top genes included ones related to inflammatory response. If the vaccine works as intended, the body will start producing the proteins soon after injection. Accessibility Scissors indicate potential spike-processing host proteases., Evolution of coronavirus spikes. I further discuss the evolution of these two critical functions of coronavirus spike proteins, receptor recognition and membrane fusion, in the context of the corresponding functions from other viruses and host cells. eCollection 2021. Pharmaceuticals (Basel). The Oxfordvaccineachieves this by introducing the spike protein gene via an adenovirus vector. 8600 Rockville Pike PMC As compared to the M and E proteins that are primarily involved in virus assembly, the S protein plays The purpose of Marijuana and the Cannabinoids is to present in a single volume the comprehensive knowledge and experience of renowned researchers and scientists. if so what are some ways to mitigate damage or prevent further degeneration. 2021;47(4):789-804. doi: 10.1134/S1068162021040130. She apparently developed some sort of serious adverse reaction on March 1. It is a little shocking, to say the least, to hear that todays vaccines were deliberately designed to function asself-replicating vaccines. doi: 10.1016/j.molcel.2020.04.022. Science. Found insideThis section reviews classical antimicrobial and phytomedical approaches as well as the application of nanotechnology against respiratory pathogens. Bethesda, MD 20894, Copyright Drugs that Might Be Possibly Used for Treatment of COVID-19 Patients. Offersgaard A, Duarte Hernandez CR, Pihl AF, Costa R, Venkatesan NP, Lin X, Van Pham L, Feng S, Fahne U, Scheel TKH, Ramirez S, Reichl U, Bukh J, Genzel Y, Gottwein JM. Posted on May 6th, 2021 by Dr. Francis Collins. doi: 10.1038/s41586-020-2012-7. Found insideVirology Division. International Union of Microbiological Societies. Bookshelf Transmembrane (TM) domain with its tripartite structure (juxtamembrane aromatic part in blue, central hydrophobic part in pink, and cysteine-rich part in purple) and the cytoplasmic tail that anchors inside the viral membrane. The child received her second (Dose 2) experimentalPfizer mRNA shot on February 25. The book covers the latest methods of using carrier ampholytes in the 1st dimension, casting and running immobilized pH gradient 2-D gels, MALDI-TOF-based peptide mapping, automated tandem mass spectrometry, and nanoelectrospray ionization What could go wrong? The spike protein binds to the ACE2 receptor on cells, downregulates their function, and causes damage to the endothelium cells that line lung tissue and blood vessels. Found insideThis book presents an entirely new approach to analysis of biomolecular in teractions, in particular protein-protein and protein-DNA interactions, based on the assumption that these interactions are electromagnetic in nature. ( A ) An insertion of 12, Hydrophobicity ( A ) and protein isoelectric point ( B ) plots of, Transmembrane (TM) domain with its tripartite structure (juxtamembrane aromatic part in blue, central, Two amino acid replacements that stabilize the spike protein at the prefusion state., MeSH It seems like the spike proteins tips were tearing through body tissue instead of repairing themcausing highly uncommon side effects of respiratory diseases. The Spike of SARS-CoV-2: Uniqueness and Applications. Moreover, the spike protein produced by the vaccine mRNA travels through bloodstream and vaccine mRNA travels to multiple organs throughout the body. The SARS-CoV-2 virus has several proteins that inhibit our own cells protein replication so the virus can be replicated instead. the tissue damage associated with Covid-19? I highlighted the relevance of structural domains and dynamics to vaccine development, and discussed reasons for the spike protein to be frequently featured in the conspiracy theory claiming that SARS-CoV-2 is artificially created. 2021 Jul 3;9(7):734. doi: 10.3390/vaccines9070734. Nat. SARS was the ?rst new plague of the twenty-?rst century. Within months, it spread worldwide from its birthplace in Guangdong Province, China, affecting over 8,000 people in 25 countries and territories across ?ve continents. The information you will receive with our consultations is for informational purposes only under the rights guaranteed by the First Amendment of the Constitution for the United States of America, and should not in any way be used as a substitute for the advice of a physician or other licensed health care practitioner. As the pandemic and vaccine disaster bites civilization deeper, one has to read the excuses for the terrifying world of genetic engineering. Introduction to coronaviruses and their spike proteins. It is hard to believe, and it is certainly new, that a virus can actually cause long-term changes to an infected persons genes. SARS-CoV-2 Spike Protein May Damage Mitochondrial Function Other research suggests the SARS-CoV-2 spike protein can have a serious impact on your mitochondrial function, which is imperative for good health, innate immunity and disease prevention of all kinds. Implementation of Adenovirus-Mediated Pulmonary Expression of Human ACE2 in HLA Transgenic Mice Enables Establishment of a COVID-19 Murine Model for Assessment of Immune Responses to SARS-CoV-2 Infection. The other two vaccines deliver the spike protein gene directly as mRNA wrapped in a nanoparticle. Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry. 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